Professor

배규운 (Gyu-Un Bae)

배규운교수

Laboratory for Cell Therapy

College of Pharmacy, Sookmyung Women’s University, 52 Hyochangwon-Gil, Yongsan-Gu, Seoul, 140-742, Korea
Office: +82-2-2077-7629
E-mail: gbae@sm.ac.kr

Education

B.S. College of Pharmacy, Sungkyunkwan University, Korea
M.S. Department of Biochemistry and Molecular Biology, College of Pharmacy, Sungkyunkwan University
Ph.D. Department of Biochemistry and Molecular Biology, College of Pharmacy, Sungkyunkwan University

Appointments and Research experience

  • 2003 – 2004: Research Fellow, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
  • 2004 – 2007: Research Fellow, Department of Developmental & Regenerative Biology, Mount Sinai School of Medicine, USA
  • 2007 – 2011: Research Professor, Department of Molecular Cell Biology, School of Medicine, Sungkyunkwan University, Korea
  • 2011 – present: Professor, College of Pharmacy, Sookmyung Women’s University, Korea

Awards & Selections

  • 2020 – Selected as an excellent lecturer (Sookmyung Women’s University)
  • 2020 – Current: Editorial Board
    – International Journal of Environmental Research and Public Health (IJERPH),
    – Section Board for ‘Toxicology and Public Health’ published by MDPI
  • 2019 – Current: Editorial Board
    – Molecular Medicine Reports, Spandodidos publications
  • 2017 – 2018 : Editorial Board
    – Archives of Pharmacal Research
  • 2016 – 2018
    – Korea Research Foundation Review Board (한국연구재단 기초연구본부 의약학단 전문위원)
  • 2013
    – Top 100 Scientists of the World (International Biographical Center, Cambridge, England)
    – Leading Scientists of the World (International Biographical Center, Cambridge,  England)
    – CAMBRIDGE CERTIFICATE for Outstanding Scientific Achievement (International Biographical Center, Cambridge, England)
  • 2012
    – International Specialty Journal Excellent Thesis Incentive (Sookmyung Women’s University, Am J Hum Genet (Cell Press) 2011, IF 10.603)
  • 2010
    – Samsung Life Science Research Institute Research Award (FASEB J. 2009, IF 6.401)
  • 2009
    – Samsung Life Science Research Institute Research Award (J Cell Biol. 2008, IF 9.120)
  • 2008
    – Selected by Faculty of 1000 Biology (J Cell Biol. 2008, IF 9.120)
    – Selected by Faculty of 1000 Biology (J Biol Chem. 2008, IF 5.520)

Columns

[의과학 칼럼] 줄기세포 활성화 어디까지 왔나 (디지털타임스의 의과학칼럼 2016년 3월2일(수)에 게재)

http://www.dt.co.kr/contents.html?article_no=2016030202103951607001

 

Representative Publications

  • [26]

    Yun CE, So HK, Vuong TA, Na MW, Anh S, Lee HG, Kim KH, Kang JS, Bae GU*, Lee SJ*

    "Aronia upregulates myogenic differentiation and augments muscle mass and function through muscle metabolism"
  • Front Nutr (20211101). [IF 6.576]
  • JCR 13.07%

  • [25]

    Bae JH, Hong M, Jeong HJ, Kim H, Lee SJ, Ryu D, Bae GU, Cho SC, Lee YS, Krauss RS, Kang JS

    "Satellite cell-specific ablation of Cdon impairs integrin activation, FGF signalling, and muscle regeneration"
  • Journal Cachexia Sarcopenia Muscle 2020 Aug;11(4):1089-1103. doi: 10.1002/jcsm.12563. Epub 2020 Feb 27. (20200801). [IF 12.910] Link
  • JCR 0.94%

  • [24]

    Jeong HJ*, Lee SJ*, Lee HJ, Kim HB, Vuong TA, Cho H, BAE GU*, Kang JS*

    "Prmt7 promotes myoblast differentiation via methylation of p38MAPK on arginine residue 70"
  • Cell Death Differ 2020 Feb;27(2):573-586. doi: 10.1038/s41418-019-0373-y. Epub 2019 Jun 26. (20200201). [IF 15.828] Link
  • JCR 3.87%, Nature Publishing Group

  • [23]

    Go GY, Jo A, Seo DW, Kim WY, Kim YK, So EY, Chen Q, Kang JS, Bae GU*, Lee SJ*

    "Ginsenoside Rb1 and Rb2 upregulate Akt/mTOR signaling-mediated muscular hypertrophy and myoblast differentiation"
  • J Ginseng Res 2020 May;44(3):435-441. doi: 10.1016/j.jgr.2019.01.007. Epub 2019 Jan 31. (20200501). [IF 6.060] Link
  • JCR 1.72%

  • [22]

    Lee SJ, Vuong TA, Go GY, Song YJ, Lee S, Lee SY, Kim SW, Lee J, Kim YK, Seo DW, Kim KH, Kang JS, Bae GU

    "An isoflavone compound daidzein elicits myoblast differentiation and myotube growth"
  • J Funct Foods 38PA (2017) pp. 438-446 (20171101). [IF 3.973] PDFLink
  • JCR 6.40%

  • [21]

    Lee SJ, Hwang J, Jeong HJ, Yoo M, Go GY, Lee JR, Leem YE, Park JW, Seo DW, Kim YK, Hahn MJ, Han JH, Kang JS, Bae GU

    "PKN2 and Cdo Interact to Activate AKT and Promote Myoblast Differentiation"
  • Cell Death Dis 2016 Oct 20;7(10):e2431. doi: 10.1038/cddis.2016.296. (20161020). [IF 5.965] PDFLink
  • Nature Publishing Group

  • [20]

    Yi SA, Um SH, Lee J, Yoo JH, Bang SY, Park EK, Lee MG, Nam KH, Jeon YJ, Park JW, You JS, Lee SJ, Bae GU, Rhie JW, Kozma SC, Thomas G, Han JW

    "S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis"
  • Mol Cell (Cell Press) 2016 May 5;62(3):443-52. doi: 10.1016/j.molcel.2016.03.011. Epub 2016 Apr 14. (20160501). [IF 14.018] PDFLink
  • Cover Story, JCR 1.40%

  • [19]

    Yoo M, Kim BG, Lee SJ, Jeong HJ, Park JW, Seo DW, Kim YK, Lee HY, Han JW, Kang JS, Bae GU

    "Syntaxin 4 regulates the surface localization of a promyogenic receptor Cdo thereby promoting myogenic differentiation"
  • Skelet Muscle 5:28. doi: 10.1186/s13395-015-0052-8. eCollection 2015. (201509). [IF 3.738] PDFLink
  • [18]

    Kwon YR, Jeong MH, Leem YE, Lee SJ, Kim HJ, Bae GU*, Kang JS*

    "The Shh coreceptor Cdo is required for differentiation of midbrain dopaminergic neurons"
  • Stem Cell Res 13(2):262-74. doi: 10.1016/j.scr.2014.07.004. Epub 2014 Jul 27. (201409). [IF 3.912] PDFLink
  • Cover Story, JCR 12.50%

  • [17]

    Tran P, Ho SM, Kim BG, Vuong TA, Leem YE, Bae GU*, Kang JS*

    "TGF-β-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) interact with the promyogenic receptor Cdo to promote myogenic differentiation via activation of p38MAPK pathway"
  • J Biol Chem 287(15):11602-15. doi: 10.1074/jbc.M112.351601. Epub 2012 Feb 15. (201204). [IF 4.651] PDFLink
  • [16]

    Lee HJ, Bae GU, Leem YE, Choi HK, Kang TM, Cho H, Kim ST, Kang JS

    "Phosphorylation of Stim1 at serine 575 via netrin-2/Cdo-activated ERK1/2 is critical for the promyogenic function of Stim1"
  • Mol Biol Cell 23(7):1376-87. doi: 10.1091/mbc.E11-07-0634. Epub 2012 Feb 1. (201204). [IF 4.803] Link
  • [15]

    Bae GU, Domené S, Roessler E, Schachter K, Kang JS, Muenke M, Krauss RS

    "Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors"
  • Am J Hum Genet (Cell Press) 89(2):231-40. doi: 10.1016/j.ajhg.2011.07.001. Epub 2011 Jul 28. (201108). [IF 10.603] PDFLink
  • JCR 4.80%

  • [14]

    Zhang W, Hong M, Bae GU, Kang JS, Krauss RS

    "Boc modifies the holoprosencephaly spectrum of Cdo mutant mice"
  • Dis Model Mech 4(3):368-80. doi: 10.1242/dmm.005744. Epub 2010 Dec 23. (201105). [IF 4.937] PDFLink
  • Cover Story

  • [13]

    Bae GU, Lee JR, Kim BG, Han JW, Leem YE, Lee HJ, Ho SM, Hahn MJ, Kang JS

    "Cdo interacts with APPL1 and activates Akt in myoblast differentiation."
  • Mol Biol Cell 21(14):2399-411. doi: 10.1091/mbc.E09-12-1011. Epub 2010 May 19. (201007). [IF 5.861] PDFLink
  • [12]

    Bae GU, Yang YJ, Jiang G, Hong M, Lee HJ, Tessier-Lavigne M, Kang JS, Krauss RS

    "Neogenin regulates skeletal myofiber size and focal adhesion kinase and extracellular signal-regulated kinase activities in vivo and in vitro"
  • Mol Biol Cell 20(23):4920-31. doi: 10.1091/mbc.E09-06-0491. Epub 2009 Oct 7. (200912). [IF 5.979] PDFLink
  • [11]

    Bae GU, Kim BG, Lee HJ, Oh JE, Lee SJ, Zhang W, Krauss RS, Kang JS

    "Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation"
  • Mol Cell Biol 29(15):4130-43. doi: 10.1128/MCB.00199-09. Epub 2009 May 26. (200908). [IF 6.057] PDFLink
  • [10]

    Oh JE*, Bae GU*, Yang YJ, Yi MJ, Lee HJ, Kim BG, Krauss RS, Kang JS

    "Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway"
  • FASEB J 23(7):2088-99. doi: 10.1096/fj.08-119255. Epub 2009 Feb 25. (200907). [IF 6.401] PDFLink
  • [9]

    Lee EK*, Bae GU*, You JS, Lee JC, Jeon YJ, Park JW, Park JH, Ahn SH, Kim YK, Choi WS, Kang JS, Han G, Han JW

    "Reversine increases the plasticity of lineage-committed cells toward neuroectodermal lineage"
  • J Biol Chem 284(5):2891-901. doi: 10.1074/jbc.M804055200. Epub 2008 Nov 17. (200901). [IF 5.328] PDFLink
  • [8]

    Kang JS*, Bae GU*, Yi MJ, Yang YJ, Oh JE, Takaesu G, Zhou YT, Low BC, Krauss RS

    "A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiation"
  • J Cell Biol 182(3):497-507. doi: 10.1083/jcb.200801119. Epub 2008 Aug 4. (200808). [IF 9.120] PDFLink
  • JCR 9.20%, Selected by Faculty of 1000 Biology.

  • [7]

    Bae GU, Gaio U, Yang YJ, Lee HJ, Kang JS, Krauss RS

    "Regulation of myoblast motility and fusion by the CXCR4-associated sialomucin, CD164."
  • J Biol Chem 283(13):8301-9. doi: 10.1074/jbc.M706730200. Epub 2008 Jan 27. (200803). [IF 5.520] PDFLink
  • Selected by Faculty of 1000 Biology

  • [6]

    Lee J, Park SY, Lee EK, Park CG, Chung HC, Rha SY, Kim YK, Bae GU, Kim BK, Han JW, Lee HY

    "Activation of hypoxia-inducible factor-1alpha is necessary for lysophosphatidic acid-induced vascular endothelial growth factor expression"
  • Clin Cancer Res 12(21):6351-8 (200611). [IF 6.177] PDFLink
  • [5]

    Takaesu G, Kang JS, Bae GU, Yi MJ, Lee CM, Reddy EP, Krauss RS

    "Activation of p38alpha/beta MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo"
  • J Cell Biol 175(3):383-8. Epub 2006 Oct 30. (200611). [IF 10.152] PDFLink
  • [4]

    Kwon SH, Ahn SH, Kim YK, Bae GU, Yoon JW, Hong S, Lee HY, Lee YW, Lee HW, Han JW

    "Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells."
  • J Biol Chem 277(3):2073-80. Epub 2001 Nov 6. (200201). [IF 6.696] PDFLink
  • [3]

    Han JW, Ahn SH, Kim YK, Bae GU, Yoon JW, Hong S, Lee HY, Lee YW, Lee HW

    "Activation of p21(WAF1/Cip1) transcription through Sp1 sites by histone deacetylase inhibitor apicidin: involvement of protein kinase C"
  • J Biol Chem 276(45):42084-90. Epub 2001 Sep 10. (200111). [IF 7.258] PDFLink
  • [2]

    Han JW, Ahn SH, Park SH, Wang SY, Bae GU, Seo DW, Kwon HK, Hong S, Lee HY, Lee YW, Lee HW

    "Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin"
  • Cancer Res 60(21):6068-74. (200011). [IF 8.302] PDFLink
  • [1]

    Bae GU, Seo DW, Kwon HK, Lee HY, Hong S, Lee ZW, Ha KS, Lee HW, Han JW.

    "Hydrogen peroxide activates p70(S6k) signaling pathway."
  • J Biol Chem 274(46):32596-602. (199911). [IF 7.258] PDFLink